This paper discusses the flight CONTROL strategy based on ADAPTIVE Dynamic Inversion (ADI) with two-time-scale separation for airplane. Because of nonlinear behavior of flight dynamics, the flight CONTROL problem is a rather important and complex issue. In addition to traditional methods, e.g., classic CONTROLler, Dynamic inversion methods, fuzzy and neural networks have been used. After reviewing these methods, Combination ADAPTIVE dynamic inversion Method is designed. In this structure, the CONTROL system attempts to track the angle of attack, the sideslip angle and the roll angle in wind frame (m, a, b). Six degree-of-freedom nonlinear equations of motion are considered for tracking the input commands. Dynamic inversion technique needs an exact and accurate flight dynamics, and to avoid this problem, we use an ADAPTIVE CONTROLler. Two-timescale based system dynamics are divided into slow outer variables and fast inner variables. ADAPTIVE CONTROLler and Dynamic inversion algorithm are used in inner and outer loops, respectively. The performance of the proposed method compares with Full Dynamic Inversion (DI) method. Simulation results demonstrated the efficacy of ADAPTIVE Dynamic Inversion CONTROLler.